Induction of apoptosis by herpes simplex virus type 1.

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چکیده

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Induction of apoptosis by herpes simplex virus type 1.

Although herpes simplex virus type 1 (HSV-1) does not induce apoptosis in infected HEp-2 cells, in the presence of cycloheximide infection induced apoptosis with characteristic morphological changes as well as endonucleosomal DNA cleavage. The induction of apoptosis without de novo protein synthesis suggests that a structural protein of the HSV-1 virion is responsible for the observed apoptosis.

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ژورنال

عنوان ژورنال: Journal of General Virology

سال: 1997

ISSN: 0022-1317,1465-2099

DOI: 10.1099/0022-1317-78-11-2909